Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance
نویسندگان
چکیده
منابع مشابه
Understanding the roles of RecQ helicases in the maintenance of genome integrity and suppression of tumorigenesis.
RecQ helicases are evolutionarily conserved enzymes required for the maintenance of genome stability. Mutations in three of the five known human RecQ helicase genes cause distinct clinical disorders that are characterized by genome instability and cancer predisposition. Recent studies have begun to reveal the cellular roles of RecQ helicases and how these enzymes may prevent tumorigenesis at th...
متن کاملRecQ helicases: lessons from model organisms
RecQ DNA helicases function during DNA replication and are essential for the maintenance of genome stability. There is increasing evidence that spontaneous genomic instability occurs primarily during DNA replication, and that proteins involved in the S-phase checkpoint are a principal defence against such instability. Cells that lack functional RecQ helicases exhibit phenotypes consistent with ...
متن کاملStructural mechanisms of human RecQ helicases WRN and BLM
The RecQ family DNA helicases Werner syndrome protein (WRN) and Bloom syndrome protein (BLM) play a key role in protecting the genome against deleterious changes. In humans, mutations in these proteins lead to rare genetic diseases associated with cancer predisposition and accelerated aging. WRN and BLM are distinguished from other helicases by possessing signature tandem domains toward the C t...
متن کاملThe human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability
Bacteria and yeast possess one RecQ helicase homolog whereas humans contain five RecQ helicases, all of which are important in preserving genome stability. Three of these, BLM, WRN and RECQL4, are mutated in human diseases manifesting in premature aging and cancer. We are interested in determining to which extent these RecQ helicases function cooperatively. Here, we report a novel physical and ...
متن کاملHuman premature aging, DNA repair and RecQ helicases
Genomic instability leads to mutations, cellular dysfunction and aberrant phenotypes at the tissue and organism levels. A number of mechanisms have evolved to cope with endogenous or exogenous stress to prevent chromosomal instability and maintain cellular homeostasis. DNA helicases play important roles in the DNA damage response. The RecQ family of DNA helicases is of particular interest since...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2008
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2008.09.003